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Original Articles
- Cytological Features That Differentiate Follicular Neoplasm from Mimicking Lesions
- Kanghee Han, Hwa-Jeong Ha, Joon Seog Kong, Jung-Soon Kim, Jae Kyung Myung, Jae Soo Koh, Sunhoo Park, Myung-Soon Shin, Woo-Tack Song, Hye Sil Seol, Seung-Sook Lee
- J Pathol Transl Med. 2018;52(2):110-120. Published online January 29, 2018
- DOI: https://doi.org/10.4132/jptm.2018.01.17
- 12,926 View
- 183 Download
- 5 Web of Science
- 5 Crossref
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Abstract
PDF - Background
It is difficult to correctly diagnose follicular neoplasms (FNs) on fine-needle aspiration cytology (FNAC) because it shares many cytological features with other mimicking lesions. The aim of this study was to identify the cytological features that differentiate FNs from mimicking lesions.
Methods
We included the cytological slides from 116 cases of thyroid FN diagnosed on FNAC, and included their subsequent histological diagnoses. We evaluated the cytological architectural pattern and nuclear features of the lesions according to their histological groups.
Results
The final histological diagnoses of the 116 cases varied, and included 51 FNs (44%), 47 papillary thyroid carcinomas (40%) including follicular variant, and seventeen cellular nodular hyperplasias (15%). Regardless of the final histological diagnosis, microfollicular pattern was observed in most cases. On the other hand, trabecular pattern was identified in 34% of FNs, but not in any other lesions. Additionally, elongated nuclei and ground glass chromatin were found in only some papillary thyroid carcinomas.
Conclusions
This study shows that the trabecular pattern is a representative cytological feature of FNs that can be used to distinguish FNs from mimicking lesions. In addition, nuclear shape and chromatin pattern can be used to further confirm the diagnosis of FNs from mimicking lesions through FNAC. -
Citations
Citations to this article as recorded by
- Diagnostic implication of thyroid spherules for cytological diagnosis of thyroid nodules
Heeseung Sohn, Kennichi Kakudo, Chan Kwon Jung
Cytopathology.2024; 35(3): 383. CrossRef - Using Deep Convolutional Neural Networks for Enhanced Ultrasonographic Image Diagnosis of Differentiated Thyroid Cancer
Wai-Kin Chan, Jui-Hung Sun, Miaw-Jene Liou, Yan-Rong Li, Wei-Yu Chou, Feng-Hsuan Liu, Szu-Tah Chen, Syu-Jyun Peng
Biomedicines.2021; 9(12): 1771. CrossRef - The Role of Fine Needle Aspiration Biopsy with Bethesda System in the Evaluation of Thyroid Nodules
Gizem AKKAŞ AKGÜN, Figen ASLAN
Anadolu Kliniği Tıp Bilimleri Dergisi.2021; 26(1): 23. CrossRef - Comprehensive DNA Methylation Profiling Identifies Novel Diagnostic Biomarkers for Thyroid Cancer
Jong-Lyul Park, Sora Jeon, Eun-Hye Seo, Dong Hyuck Bae, Young Mun Jeong, Yourha Kim, Ja Seong Bae, Seon-Kyu Kim, Chan Kwon Jung, Yong Sung Kim
Thyroid.2020; 30(2): 192. CrossRef - Preoperative diagnostic categories of fine needle aspiration cytology for histologically proven thyroid follicular adenoma and carcinoma, and Hurthle cell adenoma and carcinoma: Analysis of cause of under- or misdiagnoses
Hee Young Na, Jae Hoon Moon, June Young Choi, Hyeong Won Yu, Woo-Jin Jeong, Yeo Koon Kim, Ji-Young Choe, So Yeon Park, Paula Soares
PLOS ONE.2020; 15(11): e0241597. CrossRef
- Diagnostic implication of thyroid spherules for cytological diagnosis of thyroid nodules
- Importance of Individual Ghost Cells in Fine-Needle Aspiration Cytology Diagnosis of Pilomatricoma
- Kanghee Han, Hwa-Jeong Ha, Joon Seog Kong, Jae Kyung Myung, Sunhoo Park, Jung-Soon Kim, Myung-Soon Shin, Hye Sil Seol, Jae Soo Koh, Seung-Sook Lee
- J Pathol Transl Med. 2018;52(1):45-50. Published online January 15, 2018
- DOI: https://doi.org/10.4132/jptm.2017.10.18
- 7,398 View
- 142 Download
- 2 Web of Science
- 1 Crossref
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Abstract
PDF
- Background
Although histological diagnosis of pilomatricoma is not difficult because of its unique histological features, cytological diagnosis through fine-needle aspiration cytology (FNAC) is often problematic due to misdiagnoses as malignancy.
Methods
We reviewed the cytological features of 14 cases of histologically-proven pilomatricoma from Korea Cancer Center Hospital, with a discussion on the diagnostic pitfalls of FNAC.
Results
Among 14 cases of pilomatricoma, 10 (71.4%) were correctly diagnosed through FNAC, and two (14.3%) were misdiagnosed as carcinoma. Cytologically, all cases had easily recognizable clusters of basaloid cells and foreign body-type multinucleated cells. Although ghost cells were also found in all cases, some were inconspicuous and hardly recognizable due to their small numbers.
Conclusions
An accurate diagnosis of pilomatricoma in FNAC is feasible with consideration of clinical information and close examination of ghost cells. -
Citations
Citations to this article as recorded by- A case of pilomatricoma with suspected malignancy diagnosed by intraoperative rapid cytological diagnosis
Miho YOSHIDA-TANAKA, Kazuya KURAOKA, Naoko YASUMURA, Arisa KAN, Yumi SAIKI, Akihiro KAGAWA, Akihisa SAITO, Kiyomi TANIYAMA
The Journal of the Japanese Society of Clinical Cytology.2019; 58(3): 133. CrossRef
- A case of pilomatricoma with suspected malignancy diagnosed by intraoperative rapid cytological diagnosis
- The Significance of TROP2 Expression in Predicting BRAF Mutations in Papillary Thyroid Carcinoma
- Joon Seog Kong, Hyeon Jin Kim, Min-Jung Kim, Areumnuri Kim, Dalnim Lee, Kanghee Han, Sunhoo Park, Jae Soo Koh, Jae Kyung Myung
- J Pathol Transl Med. 2018;52(1):14-20. Published online December 11, 2017
- DOI: https://doi.org/10.4132/jptm.2017.10.17
- 7,659 View
- 232 Download
- 9 Web of Science
- 9 Crossref
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Abstract
PDF
- Background
Trophoblast antigen 2 (TROP2) is a human trophoblast cell-surface glycoprotein that is overexpressed in several types of epithelial cancers, and is suggested to be associated with an unfavorable prognosis. BRAF mutations are the most common genetic alteration in papillary thyroid carcinoma (PTC). We evaluated the correlation between TROP2 expression and BRAF mutation in PTC.
Methods
First, we carried out pyrosequencing for BRAF mutations and immunohistochemistry for TROP2 expression with a tissue microarray consisting of 52 PTC cases. Membranous staining in at least 5% of tumor cells was designated as positive staining and we analyzed the relationship between TROP2 expression and diverse clinicopathological factors, including BRAF mutation. Second, we tested TROP2 mRNA expression in three thyroid cancer cell lines with BRAF mutations (BCPAP, SNU790, and 8505C) and a normal thyroid cell line. Additionally, we checked TROP2 protein levels in a normal thyroid cell line after introduction of the BRAF V600E mutation.
Results
In this study, 21 of 26 cases with BRAF mutation showed TROP2 immunoreactivity, whereas all 26 cases without BRAF mutation showed no immunoreactivity for TROP2 with a statistically significant difference (p<.001). Upregulation of TROP2 mRNA was observed in all three thyroid cancer cell lines, but not in the normal thyroid cell line. Interestingly, however, the TROP2 expression was increased in the normal thyroid cell line after introduction of the BRAF V600E mutation.
Conclusions
Based on these results, we concluded that TROP2 expression is significantly associated with BRAF mutation and that TROP2 immunohistochemistry could be used for predicting BRAF mutations or diagnosing papillary thyroid carcinoma. -
Citations
Citations to this article as recorded by- Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma
Amany Selim Attia, Samia Hussein, Hend Sameh, Amr Khalil, Ahmad Barakat Waley, Ihab Matar, Reham Sameh
Cancer Biomarkers.2024; 39(3): 211. CrossRef - TROP2 is a Good Indicator for Infiltrative Nature of Carcinoma Rather than Diagnosing Malignancy in Thyroid
E. Kılınc, P. Gunes, A. Doganer
Indian Journal of Otolaryngology and Head & Neck Surgery.2022; 74(S2): 2560. CrossRef - Advances in Trop2-targeted therapy: Novel agents and opportunities beyond breast cancer
Xinlin Liu, Junwen Deng, Yang Yuan, Wujun Chen, Wenshe Sun, Yanhong Wang, Haiming Huang, Bing Liang, Tao Ming, Jialian Wen, Binghuan Huang, Dongming Xing
Pharmacology & Therapeutics.2022; 239: 108296. CrossRef - Knockdown of Trop2 inhibits proliferation and migration and induces apoptosis of endometrial cancer cells via AKT/β‐catenin pathway
Xiaotong Sun, Guangyang Xing, Cui Zhang, Kun Lu, Yuqiong Wang, Xiyan He
Cell Biochemistry and Function.2020; 38(2): 141. CrossRef - Can TROP2 be used as a prognostic marker in endometrioid endometrial carcinoma?
SerkanY Çelik, Özgürİlhan Çelik
Indian Journal of Pathology and Microbiology.2020; 63(3): 418. CrossRef - Diagnostic Value of TROP-2 and CK19 Expression in Papillary Thyroid Carcinoma in Both Surgical and Cytological Specimens
Asmaa Gaber Abdou, Mohammed Shabaan, Rania Abdallha, Nehal Nabil
Clinical Pathology.2019; 12: 2632010X1986304. CrossRef - Evaluation of Diagnostic Utility of Immunohistochemistry Markers of TROP-2 and HBME-1 in the Diagnosis of Thyroid Carcinoma
Nooshin Zargari, Maral Mokhtari
European Thyroid Journal.2019; 8(1): 1. CrossRef - The diagnostic value of TROP-2, SLP-2 and CD56 expression in papillary thyroid carcinoma
Xueyang Yang, Yifang Hu, He Shi, Chengzhou Zhang, Zhixiao Wang, Xiaoyun Liu, Huanhuan Chen, Lijuan Zhang, Dai Cui
European Archives of Oto-Rhino-Laryngology.2018; 275(8): 2127. CrossRef - TROP2 promotes cell proliferation and migration in osteosarcoma through PI3K/AKT signaling
Qing‑Zhi Gu, Abulimiti Nijiati, Xing Gao, Kai‑Liang Tao, Cheng‑Duo Li, Xue‑Peng Fan, Zheng Tian
Molecular Medicine Reports.2018;[Epub] CrossRef
- Diagnostic and prognostic utility of TROP-2, SLP-2, and CXCL12 expression in papillary thyroid carcinoma
Brief Case Report
- Biliary Granular Cell Tumor
- Changwon Jung, Ilyeong Heo, Sang Bum Kim, Sunhoo Park, Soo Youn Cho
- J Pathol Transl Med. 2015;49(1):89-91. Published online January 15, 2015
- DOI: https://doi.org/10.4132/jptm.2014.10.07
- 7,777 View
- 57 Download
- 5 Web of Science
- 4 Crossref
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Citations
Citations to this article as recorded by- Granular cell tumor of the gallbladder: case report and review of the literature
Walid E Abdelrahim, Salwa O Mekki, Fatima M A Ali, Sarra Ahmed H Mukhtar, Kamal E Elssidig, Elthir A G Khalil, Omer Alfarog
Journal of Surgical Case Reports.2019;[Epub] CrossRef - Malignant Granular Cell Tumor of the Bile Duct
Patrick L. Quinn, Eihab Abdelfatah, Mark A. Galan, Sushil K. Ahlawat, Ravi J. Chokshi
ACG Case Reports Journal.2019; 6(8): e00193. CrossRef - Multifocal granular cell tumour of the biliary tree
Felip Vilardell, Marina Pardina, Jorge Juan Olsina, Xavier Matias-Guiu
BMJ Case Reports.2018; 11(1): e226352. CrossRef - Solitary, multiple, benign, atypical, or malignant: the “Granular Cell Tumor” puzzle
Isidro Machado, Julia Cruz, Javier Lavernia, Antonio Llombart-Bosch
Virchows Archiv.2016; 468(5): 527. CrossRef
- Granular cell tumor of the gallbladder: case report and review of the literature
Case Study
- Primary Myxoid Leiomyoma of the Liver
- Hee Seung Choi, Chang Won Jung, Soo Youn Cho, Sang Bum Kim, Sunhoo Park
- Korean J Pathol. 2014;48(1):54-57. Published online February 25, 2014
- DOI: https://doi.org/10.4132/KoreanJPathol.2014.48.1.54
- 7,601 View
- 48 Download
- 2 Crossref
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Abstract
PDF
Herein, we report a case of primary myxoid leiomyoma of the liver. A 60-year-old woman complained of upper abdominal fullness. Computed tomography showed a solid tumor (8 cm) in the liver. The patient underwent right hepatectomy and histological findings from the resected specimen revealed scattered bland spindle cells in a background of exuberant myxoid material. The tumor cells were immunoreactive for smooth muscle actin and desmin. No other lesions were found elsewhere in the body. Thus, the tumor was diagnosed as a primary myxoid leiomyoma of the liver.
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Citations
Citations to this article as recorded by- Hepatic Myxoid Leiomyoma: A Very Rare Tumor
João Fraga, Rui Caetano Oliveira, Luigi Terracciano, Mário Rui Silva, Maria Augusta Cipriano
GE - Portuguese Journal of Gastroenterology.2020; 27(5): 352. CrossRef - A Firm Hepatic Mass Cannot Be Penetrated by US-Guided Needle Biopsy
Suk Hyun Jang, Sun Moon Kim, Jang Sihn Sohn, Ki Hyun Ryu, Hyung Bin Yuk
Clinical Ultrasound.2016; 1(2): 126. CrossRef
- Hepatic Myxoid Leiomyoma: A Very Rare Tumor
Original Articles
- Fine Needle Aspiration Cytology of Parathyroid Lesions
- Ilyeong Heo, Sunhoo Park, Chang Won Jung, Jae Soo Koh, Seung-Sook Lee, Hyesil Seol, Hee Seung Choi, Soo Youn Cho
- Korean J Pathol. 2013;47(5):466-471. Published online October 25, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.5.466
- 8,688 View
- 77 Download
- 32 Crossref
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Abstract
PDF
Background There has been an increase in the use of fine needle aspiration cytology (FNAC) for the diagnosis of parathyroid lesions (PLs). Differentiation between a thyroid lesion and a PL is not easy because of their similar features. We reviewed parathyroid aspirates in our institution and aimed to uncover trends in diagnostic criteria.
Methods We selected 25 parathyroid aspirates (from 6 men and 19 women) confirmed surgically or immunohistochemically from 2006 to 2011.
Results Major architectural findings of PLs include scattered naked nuclei, loose clusters, a papillary pattern with a fibrovascular core, tight clusters, and a follicular pattern. These architectures were commonly admixed with one another. Cytological features included anisokaryosis, stippled chromatin, a well-defined cell border, and oxyphilic cytoplasm. Eighteen of the 25 patients were diagnosed with PL using FNAC. Seven patients had been misdiagnosed with atypical cells (n=2), benign follicular cells (n=2), adenomatous goiter (n=2) and metastatic carcinoma (n=1) in FNAC. Using clinicoradiologic data, the sensitivity of the cytological diagnosis was 86.7%. The cytological sensitivity decreased to 50% without this information.
Conclusions FNAC of PL is easily confused with thyroid lesions. A combination of cytological parameters and clinical data will be required to improve the diagnostic sensitivity of PLs.
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Citations
Citations to this article as recorded by- Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort
Seyfettin Ilgan, Berna İmge Aydoğan, Özdeş Emer, Cüneyd Anıl, Alptekin Gürsoy, Mustafa Cesur, Banu Bilezikçi
The Journal of Clinical Endocrinology & Metabolism.2024; 109(2): 439. CrossRef - Fine needle aspiration biopsy of parathyroid; is it meaningful? A cytologic study of 81 cases with histological and clinical correlations
Elwira Bakuła‐Zalewska, Joanna Długosińska, Agata Stanek‐Widera, Piotr Góralski, Jacek Gałczyński, Agnieszka Żyłka, Monika Durzyńska, Marek Dedecjus
Cytopathology.2024; 35(3): 362. CrossRef - Diagnosis of parathyroid incidentaloma detected on thyroid ultrasonography: the role of fine-needle aspiration cytology and washout parathyroid hormone measurements
Boeun Lee, Sae Rom Chung, Young Jun Choi, Tae-Yon Sung, Dong Eun Song, Tae Yong Kim, Jeong Hyun Lee, Jung Hwan Baek
Ultrasonography.2023; 42(1): 129. CrossRef - Intrathyroidal parathyroid adenomas: Scoping review on clinical presentation, preoperative localization, and surgical treatment
Shravan V. Gowrishankar, Rohan Bidaye, Tilak Das, Veronika Majcher, Brian Fish, Ruth Casey, Liam Masterson
Head & Neck.2023; 45(3): 706. CrossRef - A stepwise approach to fine needle aspiration cytology of lymph nodes
Yosep Chong, Gyeongsin Park, Hee Jeong Cha, Hyun-Jung Kim, Chang Suk Kang, Jamshid Abdul-Ghafar, Seung-Sook Lee
Journal of Pathology and Translational Medicine.2023; 57(4): 196. CrossRef - The Utility of Fine Needle Aspiration (FNA) Biopsy in the Diagnosis of Mediastinal Lesions
Uma Kundu, Qiong Gan, Deepak Donthi, Nour Sneige
Diagnostics.2023; 13(14): 2400. CrossRef - Case presentation of the smallest non-functional parathyroid carcinoma and review of the literature
S. Ivaniš, M. Jovanović, D. Dunđerović, G. Zorić, B. Odalović, N. Slijepčević, K. Taušanović, B. Rovčanin, M. Buzejić, D. Vučen, B. Stepanović, J. Ilić, M. Parezanović, M. Marinković, M. Stojanović, A. Tošković, I. Mojsić, V. Živaljević
European Archives of Oto-Rhino-Laryngology.2023; 280(12): 5637. CrossRef - Utility of parathyroid hormone immunocytochemistry in fine needle aspiration diagnosis of parathyroid tissue
Ruhani Sardana, Rita Abi‐Raad, Adebowale J. Adeniran, Guoping Cai
Cytopathology.2023; 34(6): 597. CrossRef - Parathyroid carcinoma: impact of preoperative diagnosis on the choice of surgical procedure
Yoshitaka Kawai, Yo Kishimoto, Hisanobu Tamaki, Takashi Fujiwara, Ryo Asato, Koji Ushiro, Shogo Shinohara, Shinpei Kada, Shinji Takebayashi, Tsuyoshi Kojima, Shuya Otsuki, Masakazu Miyazaki, Yohei Kumabe, Koichi Omori
Endocrine Journal.2023; 70(10): 969. CrossRef - The Value of Preoperative and Intraoperative Ultrasound in the Localization of Intrathyroidal Parathyroid Adenomas
Wei Zhao, Ruigang Lu, Li Yin, Bojun Wei, Mulan Jin, Chun Zhang, Ruijun Guo, Xiuzhang Lv
Journal of Investigative Surgery.2022; 35(4): 752. CrossRef - Cyto‐morphological features of parathyroid lesions: Fine‐needle aspiration cytology series from an endocrine tumor referral center
Sanna Steen, Martin Hysek, Jan Zedenius, Henrik Falhammar, Carl Christofer Juhlin
Diagnostic Cytopathology.2022; 50(2): 75. CrossRef - Non‐secreting parathyroid carcinoma in a dog
Giovanni Tremolada, Paula Schaffer, Kathryne Pitt
Veterinary Record Case Reports.2022;[Epub] CrossRef - Fine needle aspiration of an intrathyroidal parathyroid carcinoma mimicking a primary thyroid anaplastic carcinoma: A case report with review of the literature
Fatima Mir, Prih Rohra, Nfn Aakash, Karina Furlan, Ritu Ghai, Vijaya Reddy, Lin Cheng, Paolo Gattuso
Diagnostic Cytopathology.2021;[Epub] CrossRef - Fine‐needle aspiration of parathyroid adenomas: Indications as a diagnostic approach
Ayana Suzuki, Mitsuyoshi Hirokawa, Risa Kanematsu, Aki Tanaka, Naoki Yamao, Miyoko Higuchi, Toshitetsu Hayashi, Seiji Kuma, Akihiro Miya, Akira Miyauchi
Diagnostic Cytopathology.2021; 49(1): 70. CrossRef - Two-year changes of biochemical profiles and bone mineral density after percutaneous ultrasound-guided microwave ablation for primary hyperparathyroidism
Wenjun Wu, Qi Zhou, Shihao Xu, Siqin An, Feixia Shen, Huanbin Li, Xiaohua Gong, Xiaojun Chen
Endocrine.2021; 71(2): 476. CrossRef - Multimodal imaging of thyroid cancer
Katrin Brauckhoff, Martin Biermann
Current Opinion in Endocrinology, Diabetes & Obesity.2020; 27(5): 335. CrossRef - Major Clues and Pitfalls in the Differential Diagnosis of Parathyroid and Thyroid Lesions Using Fine Needle Aspiration Cytology
Hwa Jeong Ha, Eun Ju Kim, Jung-Soon Kim, Myung-Soon Shin, Insup Noh, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee
Medicina.2020; 56(11): 558. CrossRef - Comparison of ultrasound-guided percutaneous microwave ablation and parathyroidectomy for primary hyperparathyroidism
Fangyi Liu, Xiaoling Yu, Zhoulu Liu, Zhi Qiao, Jianping Dou, Zhigang Cheng, Zhiyu Han, Jie Yu, Ping Liang
International Journal of Hyperthermia.2019; 36(1): 834. CrossRef - Giant parathyroid adenoma: a case report and review of the literature
Mohamed S. Al-Hassan, Menatalla Mekhaimar, Walid El Ansari, Adham Darweesh, Abdelrahman Abdelaal
Journal of Medical Case Reports.2019;[Epub] CrossRef - Water Clear Cell Parathyroid Adenoma: A Report of Two Cases
Abdelrahman M. Radaideh, Hisham Alkhalidi, Mohamad Nusier, Mohammad Alqudah
Arab Gulf Journal of Scientific Research.2019; : 33. CrossRef - Cytological challenges in the diagnosis of intrathyroidal parathyroid carcinoma: A case report and review of literature
Meera Balakrishnan, Smiley Annie George, Sayed Hashim Rajab, Issam M Francis, Kusum Kapila
Diagnostic Cytopathology.2018; 46(1): 47. CrossRef - Association of parathyroid carcinoma and thyroid disorders: A clinical review
Alfredo Campennì, Salvatore Giovinazzo, Salvatore Antonio Pignata, Francesca Di Mauro, Domenico Santoro, Lorenzo Curtò, Francesco Trimarchi, Rosaria Maddalena Ruggeri, Sergio Baldari
Endocrine.2017; 56(1): 19. CrossRef - Fine needle cytology pre‐surgical differentiation of parathyroid neoplasms: Is it reliable?
A. Caleo, M. Vitale, L. Valvano, M. Siano, B. Angrisani, M. Forlenza, A. Massari, A. Puzziello, F. Salzano, P. Zeppa
Cytopathology.2017; 28(4): 273. CrossRef - Identification of parathyroid tissue in thyroid fine‐needle aspiration: A combined approach using cytology, immunohistochemical, and molecular methods
Robert P. Domingo, Lorna L. Ogden, Laura C. Been, Giulia C. Kennedy, S. Thomas Traweek
Diagnostic Cytopathology.2017; 45(6): 526. CrossRef - Cytomorphologic features distinguishing Bethesda category IV thyroid lesions from parathyroid
Simon Sung, Anjali Saqi, Elizabeth M. Margolskee, John P. Crapanzano
CytoJournal.2017; 14: 10. CrossRef - Core-needle biopsy for the preoperative diagnosis of follicular neoplasm in thyroid nodule screening: A validation study
Sung Hak Lee, Gyeong Sin Park, So Lyung Jung, Min-Hee Kim, Ja Seong Bae, Dong Jun Lim, Chan Kwon Jung
Pathology - Research and Practice.2016; 212(1): 44. CrossRef - Parathyroid lesions: Difficult diagnosis on cytology
Charu Agarwal, Manju Kaushal
Diagnostic Cytopathology.2016; 44(8): 704. CrossRef - Intrathyroidal parathyroid adenoma: Diagnostic pitfalls on fine‐needle aspiration: Two case reports and literature review
Chang Shi, Hongwei Guan, Wenjing Qi, Jialin Ji, Jialing Wu, Feng Yan, Huali Wang
Diagnostic Cytopathology.2016; 44(11): 921. CrossRef - Diagnostic value of GATA-3 in cytological identification of parathyroid tissues
Nami Takada, Mitsuyoshi Hirokawa, Ayana Suzuki, Miyoko Higuchi, Seiji Kuma, Akira Miyauchi
Endocrine Journal.2016; 63(7): 621. CrossRef - PARATHYROID CYTOLOGY: A DIAGNOSTIC DILEMMA
Naval Kishore Bajaj, Shrinivas Somalwar, Akhtar Mohammad, Ezhil Arasi Nagamuthu
Journal of Evidence Based Medicine and Healthcare.2016; 3(71): 3849. CrossRef - Fine-Needle Aspiration Cytology of Parathyroid Lesions
Teklu Legesse, Paul N. Staats
Pathology Case Reviews.2015; 20(5): 227. CrossRef - A nonfunctioning parathyroid carcinoma misdiagnosed as a follicular thyroid nodule
Filomena Cetani, Gianluca Frustaci, Liborio Torregrossa, Silvia Magno, Fulvio Basolo, Alberto Campomori, Paolo Miccoli, Claudio Marcocci
World Journal of Surgical Oncology.2015;[Epub] CrossRef
- Sonographic Features of Atypical and Initially Missed Parathyroid Adenomas: Lessons Learned From a Single-Center Cohort
- Early Colorectal Epithelial Neoplasm in Korea: A Multicenter Survey of Pathologic Diagnosis
- Yun Kyung Kang, So-Young Jin, Mee Soo Chang, Jung Yeon Kim, Gyeong Hoon Kang, Hye Seung Lee, Jin Hee Sohn, Ho Sung Park, Kye Won Kwon, Mi Jin Gu, Young Hee Maeng, Jong Eun Joo, Haeng Ji Kang, Hee Kyung Kim, Kee-Taek Jang, Mi Ja Lee, Hee Kyung Chang, Joon Mee Kim, Hye Seung Han, Won Ae Lee, Yoon Jung Choi, Dong Wook Kang, Sunhoo Park, Jae Hyuk Lee, Mee-Yon Cho
- Korean J Pathol. 2013;47(3):245-251. Published online June 25, 2013
- DOI: https://doi.org/10.4132/KoreanJPathol.2013.47.3.245
- 9,152 View
- 54 Download
- 1 Crossref
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Abstract
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Background The incidence of early colorectal epithelial neoplasm (ECEN) is increasing, and its pathologic diagnosis is important for patient care. We investigated the incidence of ECEN and the current status of its pathologic diagnosis.
Methods We collected datasheets from 25 institutes in Korea for the incidence of colorectal adenoma with high grade dysplasia (HGD) and low grade dysplasia in years 2005, 2007, and 2009; and early colorectal carcinoma in the year 2009. We also surveyed the diagnostic terminology of ECEN currently used by the participating pathologists.
Results The average percentage of diagnoses of adenoma HGD was 7.0%, 5.0%, and 3.4% in years 2005, 2007, and 2009, respectively. The range of incidence rates of adenoma HGD across the participating institutes has gradually narrowed over the years 2005 to 2009. The incidence rate of early colorectal carcinoma in the year 2009 was 21.2%. The participants did not share a single criterion or terminology for the diagnosis of adenoma HGD. The majority accepted the diagnostic terms that distinguished noninvasive, mucosal confined, and submucosal invasive carcinoma.
Conclusions Further research requirements suggested are a diagnostic consensus for the histopathologic diagnosis of ECEN; and standardization of diagnostic terminology critical for determining the disease code.
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Citations
Citations to this article as recorded by- Diminutive and Small Colorectal Polyps: The Pathologist's Perspective
Yun Kyung Kang
Clinical Endoscopy.2014; 47(5): 404. CrossRef
- Diminutive and Small Colorectal Polyps: The Pathologist's Perspective
- Fine-Needle Aspiration Cytology of Pleomorphic Carcinomas of the Lung
- Hee Seung Choi, Hyesil Seol, Il Yeong Heo, Chang Won Jung, Soo Youn Cho, Sunhoo Park, Jae Soo Koh, Seung-Sook Lee
- Korean J Pathol. 2012;46(6):576-582. Published online December 26, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.6.576
- 6,749 View
- 38 Download
- 5 Crossref
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Abstract
PDF
Background Pleomorphic carcinoma (PC) is a rare pulmonary malignancy. Because of its rarity and histological heterogeneity, cytopathologists might suspect PC only rarely on the basis of its cytological specimen. In addition, cytological findings from fine needle aspiration (FNA) specimens have rarely been described. Hence, we investigated the cytological features of FNA in the cases of PC.
Methods We reviewed 7 FNA specimens of PC. The patients had undergone surgical resection at the Korea Cancer Center Hospital between 2007 and 2011. The cytological features of PC were assessed and compared with the histopathological features of the corresponding surgical specimen. Immunocytochemical analysis with cytokeratin and vimentin was performed on the cell blocks.
Results The tumor cells were either dispersed or arranged in loose aggregates, and generally lacked any glandular or squamous differentiation. Pleomorphic or spindle shape tumor cells were observed, and mono-, bi-, or multi-nucleated giant cells were frequently observed. The background showed necrosis and contained numerous lymphocytes and neutrophils. Immunocytochemically, the tumor cells were positive for cytokeratin and vimentin.
Conclusions PC displays characteristic cytological features. It might therefore be possible to make an accurate diagnosis of PC by assessing the degree of nuclear atypia.
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Citations
Citations to this article as recorded by- Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations
Atreyee Basu, Andre L. Moreira, Anthony Simms, Tamar C. Brandler
Diagnostic Cytopathology.2019; 47(8): 813. CrossRef - Cytological Evaluation of Pleomorphic Carcinoma of the Lung
Kevin Kuan, Samer N. Khader, Siba El Hussein
Diagnostic Cytopathology.2019; 47(9): 961. CrossRef - Combined small cell carcinoma with giant cell carcinoma component of the lung: A case successfully diagnosed by computed tomography‑guided fine‑needle aspiration cytology
Yusuke Ebisu, Mitsuaki Ishida, Tomohito Saito, Tomohiro Murakawa, Yoshiko Uemura, Koji Tsuta
Oncology Letters.2017;[Epub] CrossRef - Pulmonary Pleomorphic Carcinoma Detected as a Result of Pneumothorax and the Subsequent Occurrence of Multiple Cystic Metastases
Hideaki Yamakawa, Masahiro Yoshida, Masami Yabe, Yuri Baba, Emiri Baba, Hiroaki Katagi, Takeo Ishikawa, Masamichi Takagi, Takeo Nakada, Tadashi Akiba, Kazuyoshi Kuwano
Case Reports in Medicine.2014; 2014: 1. CrossRef - Pulmonary pleomorphic carcinoma with multiple metastases to the right posterior knee complicated by paraneoplastic hypercalcemia
PENG-FEI LI, CHENG-HSIANG LO, SHAN-HAN YANG, PING-YING CHUNG, CHING-LIANG HO
Oncology Letters.2014; 7(2): 452. CrossRef
- Sarcomatoid carcinoma in cytology: Report of a rare entity presenting in pleural and pericardial fluid preparations
- Update on the Proposal for Creating a Guideline for Cancer Registration of the Gastrointestinal Tumors (I-2)
- Eun Sun Jung, Yun Kyung Kang, Mee-Yon Cho, Joon Mee Kim, Won Ae Lee, Hee Eun Lee, Sunhoo Park, Jin Hee Sohn, So-Young Jin
- Korean J Pathol. 2012;46(5):443-453. Published online October 25, 2012
- DOI: https://doi.org/10.4132/KoreanJPathol.2012.46.5.443
- 9,132 View
- 157 Download
- 16 Crossref
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Abstract
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Background Cancer registries play a fundamental role in cancer control and multicenter collaborative research. Recently, the need for reassessment of cancer registry criteria has arisen due to the newly released 2010 World Health Organization (WHO) classification. Accordingly, development of new coding guidelines for cancer is necessary to improve the quality of cancer registries, as well as to prevent conflicts that may arise when seeking medical insurance compensation.
Methods With funding from the Management Center for Health Promotion, 35 members of the Gastrointestinal Pathology Study Group and the Cancer Registration Committee of the Korean Society of Pathologists (KSP) participated in a second workshop for gastrointestinal tumor registration in Korea.
Results The topics of gastric epithelial tumor, colonic intramucosal carcinoma, neuroendocrine tumor (NET), gastrointestinal stromal tumor (GIST) and appendiceal mucinous tumor were discussed for new coding guidelines. A survey was then conducted among 208 members of the KSP for a consensus of the guidelines proposed in the workshop.
Conclusions Although a few issues were set aside for further discussion, such as coding for non-gastric GIST and some types of NET, the members agreed upon most of the proposed guidelines. Therefore, we suggest using the newly revised International Classification of Diseases for Oncology, 3rd edition (ICD-O-3) coding guidelines for registering gastrointestinal tumors in Korea.
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Citations
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Case Report
- Cytologic Findings of Chordoma in Fine Needle Aspiration Cytology.
- Han Suk Ryu, Min Suk Kim, Hwa Jung Ha, Jung Soon Kim, Myung Soon Shin, Sunhoo Park, Jin Haeng Chung, Jae Soo Koh, Seung Sook Lee
- Korean J Cytopathol. 2004;15(1):45-51.
- 2,716 View
- 92 Download
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Abstract
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- It is important to recognize the pathognomonic cytologic findings of chordoma, because of overlapping cytologic features between chordoma, chondrosarcoma, myxofibrillary ependymoma, and metastatic adenocarcinoma. We reviewed the cytomorphologic features of 5 cases of chordoma diagnosed by fine needle aspiration cytology at Korean Cancer Center Hospital from 1987 to 2003. Clinical and radiographic findings of each case were reviewed. Four males and one female (29-54 years) had tumors involving the sacrum. Pain was the presenting symptom in 4 cases. The three cases showed moderate to high cellularity. In all cases, typical physaliferous cells with or without cytoplasmic processes were noted. In two cases, the background was myxoid with single scattered cells. Cell clusters showing cord-like arrangement were occasionally seen. The single or clustered cells showed mild cellular pleomorphism with slightly increased nuclear/cytoplasmic ratio. Mitotic figures were not seen. In our review, the recognition of physaliferous cells is the most important feature to diagnose chordoma and to differentiate it from other lesions mimicking chordoma.
Original Articles
- Differential Diagnosis between Small Cell Carcinoma and Adenocarcinoma of Lung in Fine Needle Aspiration Cytology.
- Young Hee Choi, Jae Soo Koh, Sunhoo Park, Min Suk Kim, Soo Youn Cho, Jung Soon Kim, Hwa Jung Ha, Seung Sook Lee
- Korean J Cytopathol. 2006;17(2):120-125.
- 2,042 View
- 62 Download
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Abstract
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- Distinguishing small cell carcinoma from other lung malignancies is of great clinico-therapeutic significance. Small cell carcinoma is an aggressive tumor with a tendency to metastasize early. Survival time if untreated is low but this tumor is highly responsive to chemotherapy. We have occasionally experienced difficulties in differentiation between adenocarcinoma and small cell carcinoma of the lung in fine needle aspiration cytology (FNAC). The aim of this study was to investigate the possibility of distinguishing small cell carcinoma from adenocarcinoma of the lung in FNAC. We evaluated cytomorphological features of FNAC specimens from 62 small cell carcinomas and 57 adenocarcinomas from the lung that were confirmed by biopsy and/or immunohistochemistry on cell block. Cytomorphological details of the two tumors were compared. Nuclear smearing and nearly absent cytoplasm were the most distinct findings in small cell carcinoma compared to adenocarcinoma (p<0.05). Necrotic background, architecture and chromatin pattern, nuclear molding and nucleoli were significantly different (p<0.05). Nuclear size, nuclear membrane nature and nuclear size variation however were not helpful in distinguishing the two tumors. Combining several features described above, small cell carcinoma can be properly differentiated from adenocarcinoma on FNAC. FNAC is proposed as a diagnostic tool of small cell carcinoma of the lung in the case of inaccessibility to biopsy, and so may allow the proper therapeutic strategies to be determined in such cases.
- Cytomorphologic Comparison of Hodgkin Lymphoma and Anaplastic Large cell Lymphoma in Fine Needle Aspiration Cytology.
- Seung Sook Lee, Jae Soo Koh, Sunhoo Park, Min Suk Kim, Soo Youn Cho, Soo Young Chung, Han Suk Ryu, Jung Soon Kim, Hwa Jung Ha, Baek Youl Ryoo
- Korean J Cytopathol. 2006;17(2):126-135.
- 2,190 View
- 50 Download
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Abstract
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- To study the differentiating cytomorphological features of Hodgkin lymphoma (HL) and anaplastic large cell lymphoma (ALCL) using fine needle aspiration cytology (FNAC), cytomorphological features of 16 patients with HL (n=8) or ALCL (n=8) were analyzed. In the initial cytological diagnosis prior to biopsy, HLs were properly diagnosed in 4 out of 8 cases (4 HL, 2 atypical, 2 benign), whereas all ALCL were diagnosed as malignancies. However, correct diagnosis of non-Hodgkin lymphoma (NHL) was made in only two ALCL patients (2 NHL, 1 HL, 1 sarcoma, 4 malignancy without specific type). Overall, the percentage of large abnormal cells ranged from 30% to 90% in ALCL except for one case, whereas it was less than 5% in all 8 HL. A spectrum of atypical cells was more characteristic of ALCL. In contrast, HL showed an sharp difference between reactive lymphoid cells and neoplastic ones (bimorphic pattern). Moreover, the emergence of kidney-shaped abnormal cells or wreath-like multinucleated cells was helpful in diagnosing ALCL. The combination of thesefeatures would be useful in differentiating HL and ALCL. Nevertheless, these two types of lymphomas cannot be definitely distinguished based on cytomorphological features alone. Therefore, the aim of FNAC would be to suggest a specific diagnosis and indicate the need for a biopsy.
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